Botulinum Neuroprotein: Deep Mechanisms of Action and Clinical Consequences
Botulinum Neuroprotein: Deep Mechanisms of Action and Clinical Consequences
Course overview
An exclusive look at the molecular mechanisms of botulinum neuroprotein by Sergey Yuryevich Shelehov, Candidate of Medical Sciences, neurologist and dermatocosmetologist of the highest category with 26 years of experience in botulinum therapy.
Understanding mechanisms that few discuss, and full control over the clinical outcome — all this in one proprietary course.
During the course you will study:
The structure of the botulinum neuroprotein molecule and the role of the light and heavy chains
The mechanism of blockade of acetylcholine release and damage to the SNARE complex
Reasons for rapid and delayed onset of effect
Selection of optimal dosing and injection techniques for different facial zones
Clinical strategies to reduce the risk of adverse effects
Protocols for predicting aesthetic outcomes
Analysis of errors and review of complex clinical cases.
After the course you will understand the molecular mechanisms of botulinum toxin action, predict the clinical effect and minimize the risks of reduced therapy effectiveness.
Course lessons
Lesson 1. The Botulinum Neuroprotein Molecule and Basics of the Mechanism of Action
The history of botulinum neuroprotein use in medicine
The structure of the molecule.
The role of the transport protein complex:
Penetration of the neuroprotein into the nerve terminal
The mechanism of blockade of acetylcholine release.
Stages of botulinum neuroprotein (BNP) action
Physiology of the nervous system interaction with targets
Damage to the SNARE complex.
Disruption of synaptic transmission:
Why botulinum toxin works selectively and locally
Biological prerequisites of the clinical effect.
Lesson 2. Dynamics of Effect: From Injection to Clinical Result
Stages of clinical effect development after administration
Rapid onset of action: possible mechanisms
Early paradoxical reactions
Pharmacokinetics and pharmacodynamics of BNP behavior.
Features of interaction with the nerve terminal:
Delayed effects and their biological rationale
Resynthesis of the SNARE complex and restoration of impulse transmission
Dose-dependence and influence of concentration
Diffusion of the drug and factors affecting spread.
Lesson 3. Individual Sensitivity and Secondary Inefficacy
Individual variability of response to botulinum toxin
Causes of primary inefficacy
Secondary inefficacy
Distant effects of BNP action
Interactions with medicinal products
Formation of neutralizing antibodies.
Immunogenicity of different preparations:
Risk factors for reduced therapy effectiveness
Errors in interpretation of the clinical result
Practical conclusions for safe and predictable practice.
